Histomer Formula 301 Sleep & Peel Night Lotion – Overnight Skin Renewal

Histomer Formula 301 Sleep & Peel Night Lotion

A mild overnight peel lotion from Histomer, the Italian clinical skincare brand. The Sleep & Peel is the entry point into the Formula 301 system: a 2–3 times per week treatment that delivers progressive chemical exfoliation while you sleep, without the intensity of a daily acid serum. Eight acids work together at a controlled pH to resurface the skin surface, refine pores, even skin tone, and reveal a visibly smoother, brighter complexion by morning. Suitable for all skin types as a weekly renewal treatment, and for anyone new to acid-based skincare who wants to build tolerance gradually.

Sleep & Peel vs F301 Night Drops — which do you need?

Both products use the Formula 301 acid system, but they serve different purposes:

• Sleep & Peel Night Lotion — Used 2–3 times per week. A milder, broader-spectrum peel for general skin renewal, brightening, and maintenance. Good starting point for acid beginners or as a weekly reset for experienced users.
• F301 Anti-Age Night Drops — Used nightly. A more concentrated treatment targeting mature skin with established fine lines, wrinkles, and significant pigmentation. More active, requires daily SPF50 the following morning.

Key actives and what they do

• Glycolic Acid (AHA) — The smallest AHA molecule, penetrating deepest into the skin surface. Dissolves the bonds between dead skin cells, accelerating cell turnover and revealing fresher skin underneath. The primary exfoliating active in the Sleep & Peel formula.
• Multi-Acid Complex (8 acids total) — A blend of AHAs and PHAs working at different molecular sizes and penetration depths for comprehensive, even exfoliation without the harshness of a single high-concentration acid.
• Niacinamide (Vitamin B3) — Evens skin tone, reduces the appearance of dark spots and post-inflammatory marks, improves the skin’s barrier function, and adds a noticeable brightening effect. Works synergistically with the acids to accelerate pigmentation fading.
• Hyaluronic Acid — Maintains skin hydration throughout the exfoliation process. Prevents the dryness and tightness that can occur with acid treatments, keeping skin plump and comfortable overnight.
• Chamomile Extract — Calms redness and irritation caused by exfoliation. Soothes the skin’s inflammatory response, making the formula suitable for sensitive skin types that might otherwise react to acid treatments.

What to expect

After first use: skin feels smoother and looks more refreshed by morning. Pores appear tighter. With consistent 2–3x weekly use: progressive improvement in skin texture, reduction in surface pigmentation and dark spots, and a more even, brighter skin tone. The Sleep & Peel is a maintenance and renewal treatment — results are gradual and cumulative. For more intensive anti-aging results, pair with or progress to the F301 Anti-Age Night Drops used nightly.

Who it is for

• All skin types seeking a weekly overnight renewal and brightening treatment
• Anyone new to acid-based skincare who wants to build tolerance gradually
• Dull, uneven, or congested skin needing regular resurfacing
• Dark spots, post-acne marks, and uneven skin tone
• Anyone wanting to maintain results between professional clinic treatments
• Adults 18+

Who it is not for

• Very sensitive or reactive skin — patch test first; start with once per week
• Broken, irritated, or sunburned skin
• Anyone not willing to use SPF the following morning.  acid use without UV protection will worsen pigmentation

Always apply SPF the morning after use. For external use only. Avoid contact with eyes. Keep out of reach of children.