Histomer Formula 301 Skin Clear Night Drops – Clarifying Anti-Acne Night Serum

Histomer Formula 301 Skin Clear Night Drops

A multi-acid clarifying night serum from Histomer — the Italian clinical skincare brand. Formulated specifically for oily, impure, and acne-prone skin, the Skin Clear Night Drops work overnight to exfoliate, purify, minimize pores, reduce dark spots, and brighten skin tone. The formula combines a targeted blend of AHAs, BHAs, and PHAs with niacinamide, hyaluronic acid, and botanical extracts — delivering chemical exfoliation and active repair simultaneously while you sleep.

Active ingredients and what they do

• Gluconolactone (PHA) — A polyhydroxy acid that acts as a keratinization modulator, gently accelerating cell turnover without the irritation associated with stronger AHAs. Also chelates heavy metals and protects the skin from environmental pollutants. Suitable for sensitive skin types that cannot tolerate glycolic acid alone.
• Salicylic Acid (BHA) — A beta hydroxy acid that is oil-soluble, meaning it penetrates into the pore lining rather than just the skin surface. Dissolves excess sebum, clears congestion, and promotes cell turnover inside the pore — directly addressing the root cause of enlarged pores and blackheads.
• Glycolic, Lactic, Mandelic & Citric Acids (AHAs) — A multi-AHA complex that exfoliates the skin surface, smooths texture, reduces fine lines, and improves radiance. Each acid works at a different molecular size and penetration depth for a comprehensive exfoliation effect.
• Niacinamide (Vitamin B3) — Improves the skin’s barrier function, reduces sebum production, fades post-acne dark spots (PIH), and has a noticeable brightening effect on uneven skin tone. One of the most clinically validated ingredients for oily and acne-prone skin.
• Sodium Hyaluronate — Binds water in the skin to maintain hydration throughout the exfoliation process. Prevents the dryness and tightness that can occur with acid-based treatments.
• Opuntia (Prickly Pear) Extract — A purifying botanical with strong antioxidant, soothing, and free radical protective properties. Calms the skin’s inflammatory response to exfoliation and environmental stress.
• Centella Meristem Cells — Support skin repair and regeneration overnight, accelerating the recovery of blemish-affected areas and improving overall skin resilience.
• Baobab & Stogolovnik Extracts — Nourishing botanical actives that support skin renewal and add a protective, conditioning layer to the skin surface.

What to expect

Week 1–2: Skin feels smoother and less congested. Pores appear tighter. Active blemishes reduce in size and redness more quickly. Week 3–4: Visible improvement in skin texture, reduction in post-acne dark spots, and a more even, brighter skin tone. With consistent nightly use: progressive refinement of pores, clearer skin, and reduced frequency of new breakouts. This is a treatment product — results build over time with consistent use.

For best results — complete the F301 routine

Pair with F301 Skin Clear Day Drops and F301 Skin Clear Day Cream for a complete day-and-night oily skin treatment system. The day and night products are formulated to work synergistically — using both maximizes results and keeps skin clear, balanced, and radiant around the clock.

Who it is for

• Oily and combination skin types
• Acne-prone skin with active blemishes or post-acne dark spots
• Enlarged or congested pores
• Uneven skin tone or dull complexion
• Adults 18+ — not recommended for use during pregnancy without medical guidance due to the acid content

Important

Always apply SPF the morning after use — AHAs and BHAs significantly increase UV sensitivity. Start with every other night if new to acid-based treatments and build to nightly use as skin adjusts. Avoid use on broken, irritated, or sunburned skin. Keep out of reach of children.