Histomer Formula 301 Regenerating & Soothing Hand Cream
A professional-grade hand cream from Histomer, the Italian clinical skincare brand. Formulated to repair, soothe, and protect hands that are dry, cracked, or exposed to daily environmental stress. The F301 hand cream goes beyond standard moisturization: it combines an active regenerating complex (SRF), a calming anti-inflammatory active (Madecasoside/Calmokyne), and Centella asiatica stem cells with SPF protection, addressing dryness, irritation, aging, and UV damage simultaneously. Fast-absorbing and non-greasy, suitable for use throughout the day.
Key actives and what they do
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SRF Complex (Lactobionic + Shikimic Acid) — A dual-acid regenerating complex. Lactobionic acid is a PHA that gently exfoliates dead skin cells, stimulates collagen production, and has strong antioxidant properties. Shikimic acid activates skin regeneration, improves texture, and reduces pigmentation. Together they restore smoothness and even tone to rough, discolored hands.
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Madecasoside (Calmokyne) — A purified extract of Centella asiatica. Stimulates the production of collagen types 1 and 3, reduces inflammation, and accelerates skin restoration. Particularly effective for cracked, irritated, or sensitized skin on the hands.
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Centella Asiatica Stem Cells — A powerful stimulator of collagen and hyaluronic acid production. Increases skin elasticity, supports regeneration, and provides deep moisturization at the cellular level.
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Shea Butter — A rich emollient that seals moisture into the skin and supports barrier repair. Softens rough, dry skin and promotes restoration of the skin’s protective layer.
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Olive Oil — Deeply moisturizes and nourishes, evens skin tone, and has a regenerating effect on damaged skin.
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Sweet Orange Peel Oil — Reduces pigmentation and brightens the skin. Adds a light, fresh scent.
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Citric Acid — Gently cleanses and exfoliates, has anti-aging properties, and a sebum-regulating effect. Softens and smooths the skin surface.
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Vitamin E — A powerful antioxidant that promotes skin regeneration, fights free radical damage, and has a rejuvenating effect on aging skin.
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SPF filters — Protect the hands from UV-induced pigmentation and premature aging. Hands are one of the most sun-exposed areas of the body and among the first to show visible aging — SPF in a hand cream is a meaningful protective benefit.
What to expect
Immediate: hands feel softer and more comfortable after the first application. The cream absorbs quickly without leaving a greasy film. With consistent use 2–3 times daily: progressive improvement in skin texture, reduction in dryness and cracking, and a more even, brighter skin tone on the hands. The SRF complex and Centella stem cells deliver visible regeneration over 3–4 weeks of regular use.
Who it is for
- Dry, cracked, or rough hands from frequent washing, cleaning, or environmental exposure
- Anyone seeking anti-aging hand care with SPF protection
- Hands showing pigmentation, uneven tone, or early signs of aging
- Anyone using the Formula 301 skincare system who wants to extend the same active ingredients to their hands
- All skin types — suitable for daily use
For external use only. Avoid contact with eyes. Contains SPF, reapply after washing hands for continued sun protection.