Histomer Formula 301 Anti-Age Night Drops – Overnight Wrinkle Repair & Renewal Serum

Histomer Formula 301 Anti-Age Night Drops

The overnight serum in the Histomer Formula 301 Anti-Age system, designed for mature, aging, and combination skin. Applied each evening, the Anti-Age Night Drops deliver a concentrated 8-acid renewal treatment that works while you sleep: exfoliating the skin surface, stimulating collagen production, fading dark spots and pigmentation, and refining pores. The formula is built on Histomer’s SRF complex. an acid-based (not retinoid-based) system that delivers clinical-grade skin renewal without the irritation and photosensitivity associated with retinoids. Pair with the F301 Anti-Age Day Drops SPF50 each morning for a complete day-and-night anti-aging routine.

Key actives and what they do

• SRF Complex (Lactobionic + Shikimic Acids) — The core of the Formula 301 system. Lactobionic acid is a PHA that gently exfoliates, stimulates collagen production, and has strong antioxidant properties. Shikimic acid activates skin regeneration, improves texture, and reduces pigmentation. Together they deliver the primary renewal and resurfacing action of the Night Drops.
• Multi-AHA Complex (Glycolic, Lactic, Mandelic, Citric Acids) — Four alpha hydroxy acids working at different molecular sizes and penetration depths for comprehensive surface exfoliation. Smooths skin texture, reduces fine lines, and improves radiance. The combination of multiple AHAs at a controlled pH delivers more even results than any single acid alone.
• Calmokyne (Madecasoside) — A purified Centella asiatica extract that calms the inflammatory response to acid exfoliation, supports barrier recovery, and accelerates skin repair overnight. Prevents the irritation cycle that can occur with sustained acid use.
• Centella Meristem Cells — Stimulate collagen and hyaluronic acid production, increase skin elasticity, and support regeneration of the skin’s structural matrix overnight.
• Sodium Hyaluronate — Maintains skin hydration throughout the exfoliation process. Prevents the dryness and tightness that can occur with acid-based treatments, keeping skin plump and comfortable overnight.
• Baobab & Stogolovnik Extracts — Nourishing botanical actives that support skin renewal and provide antioxidant protection during the overnight repair cycle.

What to expect

Week 1–2: Skin may feel slightly more sensitive as the acids begin working, this is normal and temporary. Skin texture feels smoother and more refined.

Week 2–3: Visible improvement in skin tone, reduction in surface pigmentation, and softer appearance of fine lines.

Week 4+: Progressive fading of dark spots and age marks, improved elasticity, and a noticeably more radiant complexion. This is a treatment serum.  results build progressively with consistent nightly use. Using the F301 Day Drops SPF50 each morning is essential to protect the renewed skin surface and prevent UV-induced pigmentation from reforming.

Clinical use note

The F301 Anti-Age Night Drops are suitable as daily home maintenance treatments following professional procedures including Biomicroneedling, Mesotherapy, and Chemical Peeling. Used consistently after in-clinic treatments, they extend and maintain results, keeping skin healthy, radiant, and visibly improved between sessions.

For best results — complete the F301 Anti-Age routine

Pair with F301 Anti-Age Day Drops SPF50 for daytime protection and F301 Anti-Age Day Cream for hydration and comfort. The system is designed to work as a complete routine, the Night Drops resurface and renew while you sleep; the Day Drops protect and continue the anti-aging work through the day.

Who it is for

• Mature skin with visible fine lines, wrinkles, or loss of elasticity
• Dark spots, age marks, sun damage, and uneven skin tone
• Enlarged or congested pores
• Anyone seeking a clinical acid-based alternative to retinoids for overnight skin renewal
• Post-procedure maintenance after Biomicroneedling, Mesotherapy, or Chemical Peeling
• Adults 18+ — not recommended during pregnancy without medical guidance

Who it is not for

• Very sensitive or reactive skin — start with every other night and build to nightly use
• Anyone currently using retinoids — do not combine without dermatologist guidance
• Broken, irritated, or sunburned skin

Always apply SPF the morning after use. For external use only. Avoid contact with eyes. Keep out of reach of children.