Histomer Hisiris Night Repair Dermal Cream – Overnight Renewal for Sensitive Skin

A rich overnight repair cream from Histomer, the Italian clinical skincare brand. Part of the Hisiris Pro Dermis line, formulated for constitutionally sensitive skin prone to irritation, allergies, and reactivity. Works during sleep, when the skin’s natural repair processes are most active, to strengthen the skin barrier, reduce redness and dryness, counteract wrinkles and dark spots, and improve skin resilience. By morning, skin feels calmer, more even, and visibly refreshed.

Key actives and what they do

• Hisiris Complex (Proprietary Desensitizing Complex) — Histomer’s signature active across the Hisiris range. A blend of desensitizing and anti-inflammatory agents that reduce the skin’s reactivity threshold — making it less likely to react to environmental triggers, temperature changes, and topical products over time. With consistent use, the skin becomes progressively more resilient and less reactive.
• Barrier-Strengthening Lipids — Sensitive skin typically has a compromised skin barrier — the protective outer layer that prevents moisture loss and blocks irritants. The cream’s lipid complex replenishes the barrier’s structural components (ceramides, fatty acids) overnight, reducing transepidermal water loss and improving the skin’s ability to defend itself against daily stressors.
• Soothing Botanical Actives — Anti-inflammatory plant extracts that calm redness, reduce irritation, and support the skin’s natural healing response during sleep. Particularly effective for skin that ends the day feeling tight, inflamed, or reactive after environmental exposure.
• Skin Renewal Actives — Support the skin’s natural overnight cell turnover process. Improve skin tone evenness, counteract the appearance of dark spots, and progressively smooth fine lines with consistent nightly use.
• Deep Hydration Complex — A combination of humectants and emollients that restore moisture levels overnight. Sensitive skin loses moisture more rapidly than normal skin due to barrier compromise — the overnight hydration complex ensures skin wakes up plump and comfortable rather than tight and dry.

Why nighttime application matters

Skin cell renewal peaks between 11pm and 4am. During sleep, the skin’s repair mechanisms are most active, blood flow to the skin increases, and the skin is not exposed to UV, pollution, or environmental stressors. A rich, active overnight cream applied at this time delivers ingredients when the skin is most receptive — and without the competition of SPF or makeup layered on top. For sensitive skin that spends the day defending itself against triggers, nighttime is the primary window for genuine repair.

What to expect

Immediate: skin feels calmer and more comfortable after the first night. Redness and tightness are visibly reduced by morning. With consistent nightly use over 4–8 weeks: progressive strengthening of the skin barrier, reduced frequency and intensity of sensitivity reactions, improved skin tone evenness, and a more resilient, radiant complexion. The desensitizing effect builds over time — skin becomes less reactive with each week of consistent use.

Who it is for

• Constitutionally sensitive skin prone to irritation, allergies, and reactivity (Hisiris Pro Dermis)
• Skin that feels tight, dry, red, or inflamed at the end of the day
• Anyone wanting to strengthen their skin barrier and reduce long-term sensitivity
• All ages — sensitivity is not age-dependent

Who it is not for

• Sensitive vascular skin with redness, couperose, or rosacea — use Hisiris Pro Rose instead
• Mature sensitive skin with dryness, fragility, and loss of tone — use Hisiris Pro Age instead
• Anyone looking for a lightweight gel or fluid night treatment — this is a rich cream emulsion

About the Hisiris line

The Hisiris range by Histomer addresses different forms of skin sensitivity with three targeted sub-lines. Pro Dermis is for constitutionally sensitive skin prone to irritation and allergies. Pro Rose is for sensitive vascular skin with redness, couperose, or rosacea. Pro Age is for mature skin prone to dryness, fragility, and loss of tone. Each sub-line uses the same Hisiris desensitizing complex as its foundation, with additional actives tailored to the specific sensitivity type.

Clinical skincare by Histomer. Made in Italy. Dermatologically tested. For external use only. Avoid contact with eyes.